Abstract: We generalize the mathematical definition of Coulomb branches of 3-dimensional N=4 SUSY quiver gauge theories in arXiv:1503.03676, arXiv:1601.03686, arXiv:1604.03625 to the cases with symmetrizers. We obtain generalized affine Grassmannian slices of type BCFG as examples of the construction, and their deformation quantizations via truncated shifted Yangians. Finally, we study modules over these quantizations and relate them to the lower triangular part of the quantized enveloping algebra of type ADE. (Based on the joint work with Alex Weekes, arXiv:1907.06522.)