时间：14:00 - 15:00

地点：数学高等研究院报告厅

组织者：阮勇斌，黄德力，印焘， 宋海，周家耀

报告人：陈崇 Chong Chen（四川大学华西医院）

摘要：Tumor, as pathologic organs, and tumor cells are highly dynamic during tumor evolution, including tumorigenesis, metastasis, and treatment resistance. Tumor evolution is driven by both tumor cell intrinsic and extrinsic mechanisms. My laboratory is interested in the epigenetic reprogramming and lineage plasticity of tumor cells and remodeling of tumor microenvironment (TME). We have identified multiple epigenetic regulatory genes as novel tumor suppressor genes or oncogenes, revealed new lineage plasticity of resistant tumors. Recently, we found a BBB-like immune-excluding vascular barrier in neuroendocrine tumors, which contributes to their resistance to immunotherapy. I would like to discuss the complexity of tumor cells and tumors as pathologic organs at the molecular and cellular levels, and the hypothesis-driven and data-driven approaches for biomedical research.