时间：14:00 - 15:00

地点：数学高等研究院报告厅

组织者：阮勇斌，黄德力，印焘， 宋海，周家耀

报告人：刘玉 Yu Liu（四川大学华西医院）

摘要：Cancer is a genetic disease. In addition to single nucleotide variations (SNVs), chromosomal copy number variations (CNVs), such as deletions or amplifications, are common in many cancers. Tumors harboring CNVs are often associated with drug resistance, relapse, and poor survival. Thus, it is critical to understand the molecular mechanisms underlying chromosomal CNVs. Unlike SNVs, which typically affect a single gene, chromosomal deletions or amplifications involve hundreds of genes simultaneously, posing significant challenges for functional and mechanistic studies. To address this, our group has developed cancer models for several clinically relevant chromosomal deletions, including 17p13 (one of the most frequently deleted regions in cancer), demonstrated their functional roles in cancer biology, and uncovered novel underlying mechanisms.