时间：14:00 - 15:00

地点：数学高等研究院报告厅

组织者：阮勇斌，黄德力，印焘， 宋海，周家耀

报告人：钱昆（上海交通大学）

摘要：Metabolome engineering, including profiling and manipulation of small metabolites, is essential in monitoring and control the physiological and pathological process in bio-systems. Metabolic detection is the key in metabolome engineering. Despite that mass spectrometry (MS) enjoys huge application benefits over traditional methods in metabolic detection, present MS approaches, particularly laser desorption/ionization (LDI) MS techniques, urgently need designed materials as efficient matrices and their LDI mechanism is still to be explored, in order to overcome the major limitations in terms of sensitivity, selectivity, throughput, accuracy, and practicability for metabolome engineering. In this talk, we show our recent progress on the design of inorganic particles as novel matrices for LDI MS analysis and their practical application in detection of small metabolites in bio-fluids, for advanced metabolome engineering toward large-scale biomedical use.

参考文献

[1] Wang, R. et al. and Qian, K* Nature Sustainability 2024.

[2] Zhang, J. et al. and Qian, K* Advanced Materials 2024.

[3] Huang, L. et al. and Qian, K.* Matter 2019.

报告人简介：

BS/MS at Fudan University, PhD at University of Queensland, Research Fellow at Stanford University. He is now Vice Dean at National Center for Translational Medicine (Shanghai), and also Distinguished Professor (principle investigator, PI) at School of Biomedical Engineering, Shanghai Jiao Tong University. His research is focused on development and commercialization of ultra-sensitive and high-throughput bio-analytical methods and mass spectrometry techniques towards large-scale biomedical use through design, synthesis, and engineering of materials and devices. He has co-authored over 200 peer-reviewed articles in top international journals, including Cell, Cell Metabolism, Nature Sustainability et al. Dr. Qian has attracted grants from top research programs and received prestigious awards for research excellence. He held key patents and had strong connections with domestic/international industry partners.